Model-based dose finding under model uncertainty using general parametric models
نویسندگان
چکیده
منابع مشابه
Model-based dose finding under model uncertainty using general parametric models.
The statistical methodology for the design and analysis of clinical Phase II dose-response studies, with related software implementation, is well developed for the case of a normally distributed, homoscedastic response considered for a single timepoint in parallel group study designs. In practice, however, binary, count, or time-to-event endpoints are encountered, typically measured repeatedly ...
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ژورنال
عنوان ژورنال: Statistics in Medicine
سال: 2013
ISSN: 0277-6715
DOI: 10.1002/sim.6052